Detection of Circulating Hepatoma D23 Antigen and Immune Complexes in Tumour Bearer Serum
نویسندگان
چکیده
منابع مشابه
Detection of Circulating Immune Complexes
The presumed importance of circulating immune complexes (CIC) in the pathogenesis of glomerulonephritis in man is based on comparisons with animal models (Wilson and Dixon, 1976). There is much indirect evidence suggesting the activity of immune complexes in human glomerulonephritis from (i) demonstration of granular deposits of immunoglobulins and complement components in renal biopsy sections...
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In serum sickness, mechanisms by which circulating immune complexes become localized in the walls of vessels and glomeruli have been studied. In affected arteries, morphologic observations showed that circulating marker particles of carbon would rapidly deposit along the luminal surface of the internal elastic lamina. This, as in previous studies, suggested an increase in vascular permeability ...
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BACKGROUND Administration of a biotherapeutic can result in the formation of anti-drug antibodies (ADAs). The resulting ADA can potentially form immune complexes (ICs) with the drug leading to altered pharmacokinetic (PK) profiles and/or adverse events. Furthermore the presence of such complexes may interfere with accurate PK assessment, and/or detection of ADA in immunogenicity assays. Here, w...
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The possible pathologic consequences of the presence of circulating immune complexes in certain disease states has caused considerable attention to be given to the development of laboratory procedures capable of quantitatively measuring the presence of immune complexes in serum. Many assays are available which utilize differing properties of immune complexes for their detection. Examples of ass...
متن کاملCirculating Immune Complexes
A B S TRAC T The presence of circulating immune complexes in freshly drawn sera of patients with various forms of malignancies was detected by the 125I-Clq deviation test of Sobel et al. More than 50% of the 459 cancer sera showed a high inhibition of 125I-Clq uptake by sensitized sheep erythrocytes when compared with sera of50 healthy laboratory personnel. The levels were compared with levels ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1973
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1973.66